Locsin gained critical acclaim in her 2011 drama film with Aga Muhlach, In the Name of Love.
Her performance garnered her several accolades including the Star Award for Movies for Movie Actress of the Year, the Gawad PASADO Award for Pinakapasadong Aktres, and a nomination for best actress at the FAMAS Awards.
The latter was an entry to the 2006 Metro Manila Film Festival.
Locsin reunited with Gutierrez in the romantic drama film The Promise in 2007 where their roles were considered more mature than the previous films they both starred in.
Locsin starred in another fantasy-themed TV series, Majika, together with Dennis Trillo, which was aired from March to September 2006.
She studied at St James College in Quezon City for her primary education and finished high school at the University of Santo Tomas High School in Manila.
In August 2007, she attended a short-course for fashion design at Central Saint Martins College of Art and Design in London.
She played the role of Sabina, a seemingly ordinary girl who lived in the world of mortals but is unknowingly the one destined to become the most powerful female magician.
Afterwards, she was cast in Asian Treasures, opposite Robin Padilla. Her first acting appearance with the network was via Maalaala Mo Kaya in the episode "Pilat".